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The Progestin Component
Natural progesterone is difficult to manufacture, so synthetic forms similar in structure and action to natural progesterone are used in oral contraceptives. These are referred to as progestins.
Progestin can be derived from testosterone by the simple removal of a methyl group from the testosterone. This creates the derivative Norethindrone.
Progestin can also come from the addition of a methyl group to testosterone and is called Norgestrel.
Both Norethindrone and Norgestrel are structurally similar to progesterone but contain little androgenicity.
Norgestrel turns into Levonorgesterel, it’s active form and has more progesterone activity making it more useful for women facing progesterone insufficiency conditions but more likely to be acne forming.
Norethindrone derived progestins also include Norethindrone Acetate, Ethynodiol Diacetate and Lynesterol (this is not available in the U.S.)
Levonorgesterel derived progestins also include Desogestrel, Norgestimate and Gestodene (this is not available in the U.S.).
You may see either Norethindrone or Levonorgesterel or one of their derivatives on your BCP ingredient insert.
The type of progestin used in a birth control pill can also factor into how beneficial it may be to help control acne flare-ups. Some progestins have less androgenic tendencies than others.
A quick word on Depo-Provera. This long-lasting depot form of progesterone (medroxyprogesterone acetate) has occasionally been associated with acne as a side effect, and should be considered by those who are already acne-prone. Discuss this concern with your prescribing physician.
The level of androgenicity (tendency to be acne causing from highest to lowest):
Levonorgesterel > Norethindrone > Gestodene > Desogestrel > Cyrproterone Acetate (not used in BCPs, but a major anti-androgenic medication).
Dr Kunin board certified dermatologist
DERMAdoctor.com |
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Bio
Dr. Kunin is a board certified dermatologist in Kansas City, Missouri. She
received her dermatology training at the Medical College of Virginia. She has
been featured on several local television and radio news and talk shows for her
expertise in her field. She also holds a position as Associate Clinical
Instructor at the University of Kansas Medical School Department of Dermatology.
In addition to general dermatology, her interests in cosmetic dermatology
include non-surgical approaches to skin rejuvenation, including chemical peels,
Botox, Isolagen, skin care products and sclerotherapy.
A leading source of doctor recommended skin care products and information!
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