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Androgens
What exactly do androgens do? Androgens activate sebaceous glands to make sebum, that oil on the skin that for some produces a healthy glow, for others, creates a chronic oil slick. Androgens begin to form at puberty.
Androgens are responsible for those masculine qualities; acne, hair loss and hirsutism (excess facial hair) as well as an increase in both facial and body hair.
It is essential to first understand what occurs hormonally during the course of a 28-day menstrual cycle to understand what role hormones play in monthly acne.
A very simplistic review of the menstrual cycles shows estrogen levels increasing over the first 14 days, (days 1-14), until ovulation. Once the egg is released from the ovary, the levels of estrogen drop precipitously.
Overlapping the estrogen peak, starting at approximately days 12-14, the level of progesterone begins to rise. Progesterone (essentially translating to “pro” gestational state) is essential for preparing and maintaining the uterine lining for a successful pregnancy. If fertilization does not occur and the egg does not implant, progesterone levels begin to fall, assuming a “regular” cycle, menstrual flow begins at day 28.
Progesterone is made in the adrenal glands. Progesterone has qualities of both androgens and estrogen. In the best scenario, natural progesterone competes with androgens, particularly when estrogen levels drop at ovulation, helping prevent androgens from exerting their effects upon the skin.
Women can either make too much testosterone (such as in polycystic ovary syndrome/PCOS);
make too little estrogen to mask the testosterone or have a genetic predilection
towards highly sensitive skin and hair follicle cells to “normal” levels of
androgens. By far the most common cause of androgenic acne is this natural ultra
sensitivity to androgens.
DERMAdoctor.com |
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Bio
Dr. Kunin is a board certified dermatologist in Kansas City, Missouri. She
received her dermatology training at the Medical College of Virginia. She has
been featured on several local television and radio news and talk shows for her
expertise in her field. She also holds a position as Associate Clinical
Instructor at the University of Kansas Medical School Department of Dermatology.
In addition to general dermatology, her interests in cosmetic dermatology
include non-surgical approaches to skin rejuvenation, including chemical peels,
Botox, Isolagen, skin care products and sclerotherapy.
A leading source of doctor recommended skin care products and information!
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