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Diseases and Conditions

Graves' Disease

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Endocrinology:
Graves' Disease is the most common form of hyperthyroidism in people who do not take extra thyroid hormone. But what is hyperthyroidism?
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The thyroid, the largest endocrine gland, helps control metabolic rate, body temperature, and muscle tone. This butterfly-shaped gland, which is located in front of and on each side of the windpipe, secretes two hormones. The production of thyroid hormones depends on an adequate intake of dietary iodine. The thyroid gland takes what it needs and the kidneys excrete the rest. But when the body is exposed to too much thyroid hormone - which can happen in the presence of several different disorders - hyperthyroidism occurs.

Graves' Disease is an autoimmune disorder. This immune system defect causes the production of antibodies that stimulate and attack the thyroid gland, so the gland grows and overproduces thyroid hormone. These antibodies also attack eye muscle tissue and in the skin on the front of the lower legs. The cause of Graves' Disease is not known, though research is focusing on the immune system and genetic issues.

The choice of treatment is based on symptoms, individual preference and the physician's guidance. Many treatments for Graves' Disease halt the function of the thyroid gland, so the patient must take thyroid hormone pills permanently. Physicians may suggest medication, surgery or treatments specific to complications involving the eye. Graves' Disease medications may include a betablocker, extra calcium and vitamin D, anti-thyroid drugs and radioactive iodine.

Graves' Disease was named for Robert Graves, who first described the symptoms in 1835. The symptoms, which usually appear gradually, can include fatigue, weight loss, irritability, impaired sleep, irritation of the skin of the lower legs, rapid heart beat, changes in libido, muscle weakness, heat intolerance, hand tremors, blurred or double vision and increased appetite. Be aware that other conditions, from menopause to hypoglycemia, can mimic these symptoms.

More Information on the Graves' Disease Guidebook body temperature, and muscle tone. This butterfly-shaped gland, which is located in front of and on each side of the windpipe, secretes two hormones.

More Information on the Graves' Disease Guidebook

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